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Search Results for " thymidine kinase "

Targets Recommended: Apoptosis DNA/RNA Synthesis Antibacterial Antibiotic HSV

10

抑制剂 & 化合物

4

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T1454	Acyclovir Aciclovir,Acycloguanosine,阿昔洛韦	Apoptosis; DNA/RNA Synthesis; Antibacterial; Antibiotic; HSV	Apoptosis; Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology
	Acyclovir (Aciclovir) 是鸟嘌呤类似物和具有口服活性的抗病毒剂。它对HSV-1(IC50为 0.85 μM)，HSV-2(IC50为 0.86 μM) 和水痘带状疱疹病毒有活性。
T19101	2'-Fluorothymidine 2'-Deoxy-2'-fluoro-5-Methyluridine,2'-Deoxy-2'-fluoro-5-Methyluridine	Others	Others
	2'-Fluorothymidine(2'-Deoxy-2'-fluoro-5-Methyluridine) 属于胸腺嘧啶 (TdR) 和甲基尿苷的同工酶，是具有高度选择性的 2 型胸苷激酶 (TK2) 的底物。
T20436	DHQ 2,3-dihydroxy-quinoxalin,2,3-二羟基喹喔啉	ATPase	Membrane transporter/Ion channel
	DHQ (2,3-dihydroxy-quinoxalin) 是单纯疱疹病毒胸苷激酶的 ATPase 活性诱导剂。
T1643	Penciclovir 喷昔洛韦,BRL 39123,VSA 671	HCV Protease; Antifection; HSV	Microbiology/Virology; Proteases/Proteasome
	Penciclovir (BRL 39123) 是一种疱疹病毒核苷类似物 DNA 聚合酶抑制剂。它作用于HSV1 和 2，IC50分别为 0.04-1.8 μg/mL 和 0.06-4.4 μg/mL。
T71475	Bucyclovir triphosphate
	Bucyclovir triphosphate is an antiherpes and cyclic guanosine analog activated by the viral thymidine kinase to inhibit viral DNA synthesis in infected cells.
T83821	Thymidine-5'-O-(α,β-methylene)diphosphate sodium α,β-Methylenethymidine diphosphate,Thymidine-5'-O-methylenediphosphate,TMP-CP,α,β-MTDP
	TMP-CP（Thymidine-5’-O-(α,β-methylene)diphosphate）是TDP的一种水解稳定衍生物，同时也是一种thymidine kinase抑制剂（Ki = 23 µM）。它已被用作α,β-methylene-2’-deoxythymidine 5’-triphosphate合成的前体，该合成物是DNA polymerase的一种不可切割底物。
T73980	Thymidine 5′-diphosphate
	Thymidine 5′-diphosphate (dTDP) 是合成嘧啶的关键产物，通过胸苷酸激酶 (TMPK) 对 5'-单磷酸胸苷 (dTMP) 进行磷酸化反应生成，此过程需 ATP 与 Mg2+。进一步，dTDP 可被 TMPK 催化转化为胸苷 5'-三磷酸 (dTTP)。通过测量 dTDP 水平，可以评估 TMPK 活性。
T68917	Fazarabine
	Fazarabine, also known as Kymarabine, is an orally-active pyrimidine analogue of an aza-substituted cytidine in which the ribose moiety is replaced by an arabinose sugar. Similar in action to cytarabine, fazarabine is phosphorylated by deoxycytidine kinase to a triphosphate form which competes with thymidine for incorporation into DNA; its incorporation into DNA inhibits DNA synthesis, resulting in tumor cell death and tumor necrosis. The presence of deoxycytidine kinase in a tumor is a determin...
T80655	BVDU 5′-Triphosphate BVdUTP,(E)-5-(2-Bromovinyl)-dUTP	DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	BVDU 5′-Triphosphate 是带有 5′-Triphosphate 标记、针对 DNA 聚合酶的抗病毒药物。它对水痘-带状疱疹病毒（VZV）和单纯疱疹病毒 1 型（HSV-1）具有高度选择性，这种选择性归因于病毒编码的胸苷激酶对其进行特异性磷酸化的能力。
T68631	Carbetimer
	Carbetimer is a partially imidized copolymer of ethylene & maleic anhydride with average MW approx 1,200 daltons; capable of specific stimulation of immune response. Carbetimer is a low molecular weight polymer derived from ethylene and maleic anhydride with potent antineoplastic activity. Preclinical studies have shown antitumor effects against many tumor cell lines including B 16 melanoma. Its antitumor actions are felt to include both reduction of uridine and cytidine nucleoside triphosphate ...

化合物

Cat.No: T1454

Synonym: Aciclovir,Acycloguanosine,阿昔洛韦

Target: Apoptosis, DNA/RNA Synthesis, Antibacterial, Antibiotic, HSV

2'-Fluorothymidine

Cat.No: T19101

Synonym: 2'-Deoxy-2'-fluoro-5-Methyluridine,2'-Deoxy-2'-fluoro-5-Methyluridine

Target: Others

Cat.No: T20436

Synonym: 2,3-dihydroxy-quinoxalin,2,3-二羟基喹喔啉

Target: ATPase

Cat.No: T1643

Synonym: 喷昔洛韦,BRL 39123,VSA 671

Target: HCV Protease, Antifection, HSV

Bucyclovir triphosphate

Cat.No: T71475

Thymidine-5'-O-(α,β-methylene)diphosphate sodium

Cat.No: T83821

Synonym: α,β-Methylenethymidine diphosphate,Thymidine-5'-O-methylenediphosphate,TMP-CP,α,β-MTDP

Thymidine 5′-diphosphate

Cat.No: T73980

Cat.No: T68917

BVDU 5′-Triphosphate

Cat.No: T80655

Synonym: BVdUTP,(E)-5-(2-Bromovinyl)-dUTP

Target: DNA/RNA Synthesis

Cat.No: T68631

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPJ-00769	TK1 Protein, Human, Recombinant (His) cytosolic,Thymidine kinase,TK1	Human	HEK293 Cells
	Thymidine kinase 1(TK1) belongs to the thymidine kinase family. It is located in the cytoplasm, and phosphorylated on Ser-13 in mitosis during post-translational modification. Two forms of this protein have been identified in animal cells, one in cytosol TK1 and one in mitochondria TK2. Thymidine kinases have a key function in the synthesis of DNA and thereby in cell division, as they are part of the unique reaction chain to introduce deoxythymidine into the DNA. Activity of the cytosolic enzyme...
TMPK-01386	TK1 Potein, Canine, Recombinant (His) thymidine kinase-1,EC 2.7.1.21,Thymidi...	Canine	E. coli
	Thymidine kinase 1 (TK1) catalyzes the initial phosphorylation of thymidine in the salvage pathway synthesis of dTTP, an essential building block of DNA. TK1 is a cytosolic enzyme with its highest level during the S-phase of the cell cycle.
TMPJ-00905	DTYMK Protein, Human, Recombinant (His) DTYMK,TMPK,dTMP kinase,Thymidylate kinase,...	Human	HEK293 Cells
	Thymidylate kinase (DTYMK) is a ubiquitous enzyme of about 25 kD which belongs to thymidylate kinase family. DTYMK is important in the dTTP synthesis pathway for DNA synthesis. It participated in the pyrimidine metabolism pathway and dTTP biosynthesis pathway. DTYMK catalyzes the conversion of dTMP to dTDP and catalyzes the phosphorylation of thymidine 5'-monophosphate (dTMP) to form thymidine 5'-diphosphate (dTDP) in the presence of ATP and magnesium. Structural and functional analyses suggest ...
TMPY-04542	CDK2 Protein, Human, Recombinant (His) CDKN2,cyclin-dependent kinase 2,p33(CDK2)	Human	Baculovirus Insect Cells
	CDK2 is a member of the Ser/Thr protein kinase family. This protein kinase is highly similar to the gene products of S. cerevisiae cdc28, and S. pombe cdc2. It is a catalytic subunit of the cyclin-dependent protein kinase complex, whose activity is restricted to the G1-S phase, and essential for cell cycle G1/S phase transition. Cdks (cyclin-dependent kinases) are heteromeric serine/threonine kinases that control progression through the cell cycle in concert with their regulatory subunits, the c...

重组蛋白

TK1 Protein, Human, Recombinant (His)

Cat.No: TMPJ-00769

Species: Human

Expression System: HEK293 Cells

TK1 Potein, Canine, Recombinant (His)

Cat.No: TMPK-01386

Species: Canine

Expression System: E. coli

DTYMK Protein, Human, Recombinant (His)

Cat.No: TMPJ-00905

Species: Human

Expression System: HEK293 Cells

CDK2 Protein, Human, Recombinant (His)

Cat.No: TMPY-04542

Species: Human

Expression System: Baculovirus Insect Cells

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